CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.
CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.
Congenital Disorders of Glycosylation
Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.
Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.
As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.
There are 170+ different types of CDG and new types are discovered each year.
Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.
Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!
Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.
Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!
February 2, 2024
Cirnigliaro L, et al. , February 2, 2024READ MORE
January 27, 2024
Zobaroğlu-Özer P, Bora-Akoğlu G. Mol Biol Rep, January 27, 2024READ MORE
January 22, 2024
Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis
Wei X, et al. Nat Commun., January 22, 2024READ MORE
January 22, 2024
Single-center experience of congenital disorders of glycosylation syndrome screening in Tunisia: A retrospective study over a 15-year period (2007-2021)
Zidi W, et al. Arch Pediatr., January 22, 2024READ MORE
January 19, 2024
Weixel T, Wolfe L, Macnamara EF. J Genet Couns, January 19, 2024READ MORE
January 18, 2024
Targeted Proteomics Reveals Quantitative Differences in Low-Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation
Sakson R, et al. Int J Mol Sci., January 18, 2024READ MORE
January 16, 2024
Case report: A founder UGDH variant associated with developmental epileptic encephalopathy in Saudi Arabia
Alaamery M et al. Front Genet., January 16, 2024READ MORE
January 13, 2024
Inherited Retinal Degeneration Caused by Dehydrodolichyl Diphosphate Synthase Mutation-Effect of an ALG6 Modifier Variant
Monson E, et al. Int J Mol Sci, January 13, 2024READ MORE
January 4, 2024
Morava E. Mol Genet Metab., January 4, 2024READ MORE
December 29, 2023
Suzuki T. J Biochem., December 29, 2023READ MORE