CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.
CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.
Congenital Disorders of Glycosylation
Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.
Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.
As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.
There are 170+ different types of CDG and new types are discovered each year.
Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.
Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!
Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.
Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!
March 11, 2023
March 11, 2023 / Venutra, CA, United StatesREAD MORE
March 12, 2023
March 12, 2023 / Ventura, CA, United StatesREAD MORE
January 26, 2023
AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase I deficiency (PGM1-CDG)
Balakrishnan B et al. Transl Res., January 26, 2023READ MORE
January 24, 2023
Higher frequency of TEM199-CDG in the southern mediterranean area is associated with c.92G>C (p.Arg31Pro) mutation
Fiumara A et al. Eur J Med Genet. , January 24, 2023READ MORE
January 21, 2023
Neurological insights on two siblings with GM3 synthase deficiency due to novel compound heterozygous ST3GAL5 variants
Watanabe S, et al. Brain Dev., January 21, 2023READ MORE
January 20, 2023
Dhanalakshmi M et al. Med Chem Res., January 20, 2023READ MORE
January 18, 2023
Fractionated plasma N-glycan profiling of novel cohort of ATP6AP1-CDG subjects identifies phenotypic association.
Alharbi H et al. J Inherit Metab Dis., January 18, 2023READ MORE
January 18, 2023
MOGS-CDG: quantitative analysis of the diagnostic Glc3 Man tetrasaccharide and clinical spectrum of six new cases
Post MA, et al. J Inherit Metab Dis., January 18, 2023READ MORE
January 9, 2023
An induced pluripotent stem cell-derived NMJ platform for study of the NGLY1-Congenital Disorder of Deglycosylation
Sasserath T, et al. Adv Ther., January 9, 2023READ MORE
January 5, 2023
A Community-Based Participatory Framework to Co-Develop Patient Education Materials (PEMs) for Rare Diseases: A Model Transferable across Diseases
Falcão M et al. Int J Environ Res Public Health., January 5, 2023READ MORE
December 31, 2022
Kasapkara CS, Olgac A, Derinkuyu BE, Oztoprak U, Jaeken J. J Coll Physicians Surg Pak. , December 31, 2022READ MORE
December 29, 2022
Whole exome sequencing reveals several novel variants in congenital disorders of glycosylation and glycogen storage diseases in seven patients from Iran
Papi A et al. Mol Genet Genomic Med., December 29, 2022READ MORE