CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.
CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.
Congenital Disorders of Glycosylation
Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.
Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.
As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.
There are 170+ different types of CDG and new types are discovered each year.
Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.
Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!
Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.
Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!
October 30, 2023
Uzunyayla-Inci G, Kiykim E, Zubarioglu T, Yesil G, Aktuglu Zeybek C. Mol Syndromol., October 30, 2023READ MORE
October 24, 2023
Raynor A, et al. Proteomics Clin Appl., October 24, 2023READ MORE
October 24, 2023
Quantitative mapping of the in vivo O-GalNAc glycoproteome in mouse tissues identifies GalNAc-T2 O-glycosites in metabolic disorder
Yang W, et al. Proc Natl Acad Sci U S A., October 24, 2023READ MORE
October 20, 2023
Tachida Y, Hirayama H, Suzuki T. Biochim Biophys Acta Gen Subj., October 20, 2023READ MORE
October 19, 2023
Francisco R, et al. Orphanet J Rare Dis. 2023, October 19, 2023READ MORE
October 17, 2023
Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation
Kas SM, Mundra PA, Smith DL, Marais R. Sci Rep. 2023, October 17, 2023READ MORE
October 4, 2023
Polenghi M, Taverna E. Front Neurosci., October 4, 2023READ MORE
September 26, 2023
Identification of a muscle-specific isoform of VMA21 as a potent actor in X-linked myopathy with excessive autophagy pathogenesis
Cocchiararo I, et al. Hum Mol Genet., September 26, 2023READ MORE
September 23, 2023
Syndromic congenital diaphragmatic hernia: Current incidence and outcome. Analysis from the congenital diaphragmatic hernia study group registry
Burgos CM, et al. Prenat Diagn., September 23, 2023READ MORE
September 21, 2023
A Case of Congenital Disorder of Glycosylation Type 1b Presenting as Hyperinsulinemic Hypoglycemia and Failure to Thrive
Rani S, Sahai I, Misra M. JCEM Case Rep., September 21, 2023READ MORE