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A knowledge base
for the global
CDG community

CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.

CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.

Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.

Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.

As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.

170+

There are 170+ different types of CDG and new types are discovered each year.

400+

Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.

Families

Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!

Clinicians

Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.

Researchers

Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!

Join CDG Connect PIN: a worldwide CDG patient registry

Help advance progress towards improved diagnosis, treatments and cures for CDG by joining a global patient registry.

Events

February 28, 2023

Rare Disease Day 2023

February 28, 2023

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March 11, 2023

Gordon Research Seminar: Glycobiology

March 11, 2023 / Venutra, CA, United States

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March 12, 2023

Gordon Research Conference: Glycobiology

March 12, 2023 / Ventura, CA, United States

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May 16, 2023

World CDG Awareness Day 2023

May 16, 2023

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Publications

November 22, 2022

Glycan quality control in and out of the endoplasmic reticulum of mammalian cells

Harada Y et al. FEBS J., November 22, 2022

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November 21, 2022

GLUT1 is a Highly Efficient L-Fucose Transporter

Ng BG, Sosicka P, Xia Z, Freeze HH. J Biol Chem., November 21, 2022

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November 18, 2022

Chemical Therapies for Congenital Disorders of Glycosylation

Sosicka P, Ng BG, Freeze HH. ACS Chem Biol., November 18, 2022

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November 16, 2022

The O-GlcNAc cycling in neurodevelopment and associated diseases

Wenzel DM, Olivier-Van Stichelen S. Biochem Soc Trans., November 16, 2022

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November 3, 2022

Gillessen-Kaesbach-Nishimura syndrome in two fetuses from Turkey

Kaymak D, et al. Am J Med Genet A., November 3, 2022

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