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A knowledge base
for the global
CDG community

CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.

CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.

Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.

Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.

As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.


There are 170+ different types of CDG and new types are discovered each year.


Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.


Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!


Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.


Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!

Join CDG Connect PIN: a worldwide CDG patient registry

Help advance progress towards improved diagnosis, treatments and cures for CDG by joining a global patient registry.


March 1, 2024

Rare Disease Day Symposium & CDG Scientific and Family Conference

March 1, 2024 / San Diego, CA, United States



October 30, 2023

Autism Spectrum Disorder in Two Unrelated Patients with Homozygous Variants in Either ALG8 or ALG11

Uzunyayla-Inci G, Kiykim E, Zubarioglu T, Yesil G, Aktuglu Zeybek C. Mol Syndromol., October 30, 2023


October 24, 2023

“Hide and seek”: Misleading transferrin variants in PMM2-CDG complicate diagnostics

Raynor A, et al. Proteomics Clin Appl., October 24, 2023


October 20, 2023

Amino acid editing of NFE2L1 by PNGase causes abnormal mobility on SDS-PAGE

Tachida Y, Hirayama H, Suzuki T. Biochim Biophys Acta Gen Subj., October 20, 2023


October 19, 2023

Congenital disorders of glycosylation (CDG): state of the art in 2022

Francisco R, et al. Orphanet J Rare Dis. 2023, October 19, 2023


October 17, 2023

Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation

Kas SM, Mundra PA, Smith DL, Marais R. Sci Rep. 2023, October 17, 2023


October 4, 2023

Intracellular traffic and polarity in brain development

Polenghi M, Taverna E. Front Neurosci., October 4, 2023