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A knowledge base
for the global
CDG community

CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.

CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.

Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.

Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.

As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.

170+

There are 170+ different types of CDG and new types are discovered each year.

400+

Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.

Families

Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!

Clinicians

Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.

Researchers

Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!

Join CDG Connect PIN: a worldwide CDG patient registry

Help advance progress towards improved diagnosis, treatments and cures for CDG by joining a global patient registry.

Events

May 25, 2025

The 27th International Glycoconjugate Symposium

May 25, 2025 / Edmonton, AB, Canada

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July 6, 2025

The 22nd European Carbohydrate Symposium

July 6, 2025 / Gdansk, Poland

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Publications

April 4, 2025

Clinical and Molecular Features of Patients With Congenital Disorders of Glycosylation in Japan

Okamoto N, Kadoya M, Wada Y. JIMD Rep., April 4, 2025

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April 3, 2025

Mannose Phosphate Isomerase Deficiency-Congenital Disorder of Glycosylation (MPI-CDG) Type 1b: Familial Case of Thrombophilia and Liver Disorder

Ducatez F, Minacori E, Vuillaumier Barrot S, Sauvêtre G, Dabaj I. Clin Chem., April 3, 2025

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March 30, 2025

Beneficial effects of Glc-1,6-P2 modulation on mutant phosphomannomutase-2

Monticelli M, et al. Biochim Biophys Acta Mol Cell Res., March 30, 2025

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March 22, 2025

Diagnostic and Therapeutic Approaches in Congenital Disorders of Glycosylation

Raynor A, Lebredonchel É, Foulquier F, Fenaille F, Bruneel A. Handb Exp Pharmacol., March 22, 2025

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March 20, 2025

Computational profiling of molecular biomarkers in congenital disorders of glycosylation Type-I and binding analysis of Ginkgolide A with P4HB

Rahiyab M, Khan I, Ali SS, Hussain Z, Ali S, Iqbal A. Comput Biol Med., March 20, 2025

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March 19, 2025

Goal attainment in PMM2-CDG: A new approach measuring meaningful clinical outcomes

Verberkmoes S, et al. Mol Genet Metab., March 19, 2025

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March 18, 2025

Knockout of the fcsk gene in zebrafish causes neurodevelopmental defects

Liu ZX, Zou TT, Liu HH, Jia HB, Zhang XQ. Zool Res., March 18, 2025

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