CDG Hub is a knowledge base that is designed to educate researchers, clinicians, patients and families on congenital disorders of glycosylation.
CDG Hub is a nexus for curated information on more than 170+ CDG types, clinical trials, research models and resources, including a database of CDG medical experts and researchers worldwide. CDG Hub aims to unite the global CDG community, increase public awareness, and inspire collaborative research to advance scientific discoveries.
Congenital Disorders of Glycosylation
Congenital Disorders of Glycosylation (CDG) are a large group of rare, inherited disorders that are caused by defects in glycosylation.
Glycosylation is the process of assembling and adding sugar chains, called glycans, to proteins and lipids. When someone has CDG, their body cannot properly create or add glycans to proteins and lipids.
As every part of the body needs glycosylation to work properly, people with CDG have many health problems which often affect multiple body systems. There is no cure for CDG, but treatments are available to manage symptoms and many therapies are currently in development.
There are 170+ different types of CDG and new types are discovered each year.
Over 400 genes in the human genome are involved in glycosylation and mutations in more than 170 of them are known to cause CDG.
Learn everything you need to know about CDG. Discover educational resources developed specifically for families, important medical terms to know, FAQs, and connect with other CDG families near you!
Are you a healthcare professional interested in learning about CDG? Discover educational resources for clinicians and patients, CDG medical experts and centres around the world and upcoming clinical trials.
Our understanding of CDG continues to evolve as researchers around the world study what causes the disease and how it affects the body. Discover researchers who are working to better understand CDG, improve diagnosis and develop new treatments or cures. Be inspired to launch collaborative research projects to accelerate scientific discoveries on CDG!
Join CDG Connect PIN: a worldwide CDG patient registry
Help advance progress towards improved diagnosis, treatments and cures for CDG by joining a global patient registry.
July 21, 2023
6th World Conference on CDG
July 21, 2023 / Caparica, PortugalREAD MORE
November 5, 2023
Society for Glycobiology Annual Meeting 2023
November 5, 2023 / Waikoloa, HawaiiREAD MORE
June 2, 2023
A liposomal carbohydrate vaccine, adjuvanted with an NKT cell agonist, induces rapid and enhanced immune responses and antibody class switching
Jia, JX et al. J Nanobiotechnology., June 2, 2023READ MORE
May 30, 2023
Novel NUS1 variant in a Chinese patient with progressive myoclonus epilepsy: a case report and systematic review
Ji C, Zhao J, Zhang J, Wang K. Neurol Sci., May 30, 2023READ MORE
May 30, 2023
Germline C1GALT1C1 mutation causes a multisystem chaperonopathy
Erger F, et al. Proc Natl Acad Sci U S A . , May 30, 2023READ MORE
May 23, 2023
Tracer metabolomics reveals the role of aldose reductase in glycosylation
Radenkovic S, et al. Cell Rep Med., May 23, 2023READ MORE
May 23, 2023
Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools
Farooqi N, et al. Open Life Sci., May 23, 2023READ MORE
May 19, 2023
A novel variant in ALG1 gene associated with congenital disorder of glycosylation: A case report and short literature review
Xue Y, et al. Mol Genet Genomic Med. , May 19, 2023READ MORE
May 17, 2023
MAGT1 deficiency in XMEN disease is associated with severe platelet dysfunction and impaired platelet glycoprotein N-glycosylation
Kauskot A, et al. J Thromb Haemost., May 17, 2023READ MORE
May 16, 2023
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches
Himmelreich N, et al. Mol Genet Metab. 2023, May 16, 2023READ MORE
May 11, 2023
Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review
Conte F, Sam JE, Lefeber DJ, Passier R. Int J Mol Sci., May 11, 2023READ MORE
May 9, 2023
Coagulation abnormalities in a prospective cohort of 50 patients with PMM2-congenital disorder of glycosylation
De Graef D et al. Mol Genet Metab. , May 9, 2023READ MORE