Uncommon Factors Leading to Nephrotic Syndrome

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia. Apart from the traditional causes of NS, such as minimal change disease, focal segmental glomerulosclerosis, diabetes, infections, malignancies, autoimmune conditions, and nephrotoxic agents, there are also rare causes of NS, whose knowledge is of the utmost importance. The aim of this article was to highlight the less well-known causes that have a significant impact on diagnosis and treatment. […] Congenital disorders of glycosylation and Nail-Patella Syndrome emphasize the role of deranged protein processing and transcriptional regulation in glomerular injury.