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Bioinformatic prediction of putative conveyers of O-GlcNAc Transferase intellectual disability

Protein O-GlcNAcylation is a dynamic post-translational modification (PTM) that is catalysed by the enzyme O-GlcNAc transferase (OGT) and is essential for neurodevelopment and postnatal neuronal function. Missense mutations in OGT segregate with a novel X-linked intellectual disability (XLID) syndrome, the O-GlcNAc Transferase Congenital Disorder of Glycosylation (OGT-CDG). One hypothesis for the aetiology of OGT-CDG is that loss of OGT activity leads to hypo-O-GlcNAcylation of as yet unidentified, specific neuronal proteins, affecting essential embryonic and postnatal neurodevelopmental processes; however, the identity of these O-GlcNAcylated proteins is not known. Here, we used bioinformatic techniques to integrate sequence conservation, structural data, clinical data, and the available literature to identify 22 candidate proteins that convey OGT-CDG.