Disorder of nucleotide sugar synthesis and transport

Any disorder that prevents the adequate construction of nucleotide sugars, a type of activated sugar, or prevents the nucleotide sugar from entering the compartments of the cell where it is needed for glycosylation. Since nucleotide sugars are a key class of activated sugars involved in the synthesis of glycoproteins/glycolipids, disorders of nucleotide sugar synthesis and transport will negatively affect multiple glycosylation pathways.