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Disorder of nucleotide sugar synthesis

Any genetic disorder that prevents the adequate construction of nucleotide sugars, a type of activated sugar, or prevents the nucleotide sugar from entering the compartments of the cell where it is needed for glycosylation. Since nucleotide sugars are a key class of activated sugars involved in the synthesis of glycolipids/glycoproteins, disorders of nucleotide sugar synthesis will negatively affect multiple glycosylation pathways.